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People who are strictly drinking a lot more alcohol tend to have more rapid progression in their disease than someone with just strictly fatty liver disease, Jensen said

This vulnerability is often amplified in obesity, where baseline oxidative tone is elevated and polyunsaturated fatty acid (PUFA)-enriched membrane phospholipids provide oxidation-susceptible substrates [66,67,68]

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2011;6(9):e25029

While this has some inherent logic, it has not been fully explored whether it is valid to assume a linearity of the relationship between gene and serum UA in which genetic polymorphisms differentiating normal and high UA associated with, say, risk of gout are the same as those differentiating normal and low UA associated with risk of PD